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Literature summary for 2.4.1.313 extracted from

  • Nakane, T.; Angata, K.; Sato, T.; Kaji, H.; Narimatsu, H.
    Identification of mammalian glycoproteins with type-I LacdiNAc structures synthesized by the glycosyltransferase B3GALNT2 (2019), J. Biol. Chem., 294, 7433-7444 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.313

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
 Homo sapiens 5783
-
endoplasmic reticulum
-
 Cricetulus griseus 5783
-

Organism

Organism UniProt Comment Textmining
Cricetulus griseus A0A3L7H411
-
-
Homo sapiens Q8NCR0
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CHO-Lec8 cell
-
 Cricetulus griseus
-
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[low-density lipoprotein receptor-related protein 1]
-
 Cricetulus griseus UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[low-density lipoprotein receptor-related protein 1]
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + 3-O-[N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[nicastrin]
-
 Cricetulus griseus UDP + 3-O-[N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl]-L-threonyl-[nicastrin]
-
 ?

Synonyms

Synonyms Comment Organism
B3GalTN2
-
 Homo sapiens
B3GalTN2
-
 Cricetulus griseus

General Information

General Information Comment Organism
physiological function inhibition of Golgi-resident glycosyltransferase increases the abundance of B3GALNT2-synthesized type-I LacdiNAc structures. LacdiNAc presence on low-density lipoprotein receptor-related protein 1 and nicastrin depends on B3GALNT2. Most of the identified glycoproteins modified by B3GalTN2 localize to intracellular organelles, particularly to the endoplasmic reticulum. Whereas B4GALNT3 and B4GALNT4 synthesize LDN on extracellular glycoproteins, B3GALNT2 primarily transfers LacdiNAc to intracellular glycoproteins Cricetulus griseus
physiological function inhibition of Golgi-resident glycosyltransferase increases the abundance of B3GALNT2-synthesized type-I LacdiNAc structures. Most of the identified glycoproteins modified by B3GalTN2 localize to intracellular organelles, particularly to the endoplasmic reticulum. Whereas B4GALNT3 and B4GALNT4 synthesize LDN on extracellular glycoproteins, B3GALNT2 primarily transfers LacdiNAc to intracellular glycoproteins Homo sapiens